- Protein Name
- Serine/threonine-protein kinase 24 36 kDa subunit
- Gene Name
- STK24
- Organism
-
Homo sapiens
- Function
- Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
28 |
2 |
16.0 |
| DFG |
17 |
2 |
8.5 |
| PIF |
32 |
1 |
16.5 |
| DRS |
23 |
2 |
7.0 |
| DEF |
3 |
3 |
3.0 |
| MT3 |
5 |
3 |
3.0 |
| AAS |
13 |
6 |
9.0 |
| CMP |
6 |
2 |
3.0 |
| PDIG |
17 |
1 |
9.5 |
| ATP |
26 |
2 |
7.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
19 |
1 |
23 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
7 |
0 |
|
4QMZ
|
22 |
12 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
6 |
14 |
9 |
0 |
|
4QMO
|
26 |
0 |
29 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
11 |
6 |
0 |
|
3CKX
|
18 |
11 |
21 |
8 |
0 |
0 |
0 |
0 |
0 |
6 |
14 |
13 |
0 |
|
4QMX
|
17 |
3 |
27 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
14 |
21 |
0 |
|
3A7H
|
25 |
0 |
19 |
22 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4QMT
|
2 |
11 |
20 |
0 |
0 |
0 |
5 |
0 |
0 |
0 |
14 |
16 |
0 |
|
4QMS
|
0 |
0 |
20 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
12 |
24 |
0 |
|
4W8E
|
4 |
12 |
21 |
0 |
0 |
0 |
4 |
0 |
0 |
4 |
10 |
6 |
0 |
|
4QML
|
21 |
9 |
18 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
13 |
15 |
0 |
|
3ZHP
|
16 |
0 |
29 |
6 |
3 |
0 |
0 |
13 |
0 |
0 |
0 |
3 |
0 |
|
4QO9
|
13 |
0 |
22 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
15 |
23 |
0 |
|
4QMN
|
0 |
2 |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
17 |
26 |
0 |
|
3A7F
|
18 |
0 |
16 |
17 |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
11 |
0 |
|
4QMY
|
19 |
4 |
27 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
11 |
8 |
0 |
|
3A7G
|
21 |
0 |
32 |
23 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
6 |
0 |
|
4W8D
|
23 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
12 |
2 |
0 |
|
4U8Z
|
21 |
0 |
23 |
6 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
5 |
0 |
|
4QMM
|
18 |
2 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
10 |
0 |
|
3CKW
|
24 |
0 |
19 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
5 |
11 |
0 |
|
4QMQ
|
19 |
0 |
26 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
9 |
2 |
0 |
|
AFQ9Y6E0
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4QNA
|
0 |
14 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
14 |
16 |
0 |
|
4O27
|
11 |
8 |
15 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
9 |
18 |
0 |
|
4QMW
|
17 |
14 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
9 |
6 |
0 |
|
4QMU
|
0 |
9 |
24 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
11 |
4 |
0 |
|
3A7J
|
12 |
17 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4QMV
|
28 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
11 |
7 |
0 |
|
3A7I
|
19 |
13 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5 |
9 |
0 |
|
4QMP
|
22 |
3 |
29 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |