Pyrazole-based inhibitors of B-Raf kinase

PDB Details

PDB ID
3D4Q
Status
CURRENT
Deposition Date
2008-05-14
Modification Date
2010-09-08
Pubmed ID
18676143
Method
X-RAY DIFFRACTION
Resolution (Å)
2.8
UniProt Accessions
P15056

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C AAS 6 7
A N ATP 0 20
A N ATP 1 16
A N MPP 2 14
A N MPP 3 13
A N MT3 6 6
A N DFG 7 4
A N DFG 8 2
B C AAS 2 16
B N ATP 0 16
B N ATP 1 16
B N MPP 2 13
B N MT3 3 13
B N MPP 4 10
B N DFG 8 4
B N DFG 9 2

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Legend

Color Name Hit Count