- Protein Name
- Serine/threonine-protein kinase B-raf
- Gene Name
- BRAF
- Organism
-
Homo sapiens
- Function
- Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
21 |
1 |
10.0 |
| AAS |
26 |
2 |
5.5 |
| MT3 |
31 |
1 |
12.5 |
| ATP |
29 |
1 |
15.0 |
| DEF |
4 |
3 |
3.5 |
| DFG |
13 |
1 |
3.0 |
| CMP |
10 |
10 |
10.0 |
| EDI |
23 |
7 |
16.5 |
| DRS |
17 |
17 |
17.0 |
| PIF |
20 |
6 |
13.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
10 |
5 |
30 |
0 |
43 |
0 |
0 |
0 |
0 |
12 |
1 |
0 |
3 |
|
4CQE
|
16 |
0 |
17 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4YHT
|
15 |
0 |
0 |
0 |
18 |
0 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4XV2
|
15 |
0 |
20 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4XV9
|
7 |
0 |
26 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4WO5
|
14 |
0 |
18 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
5FD2
|
7 |
0 |
18 |
0 |
12 |
0 |
0 |
0 |
0 |
14 |
0 |
0 |
0 |
|
2FB8
|
13 |
0 |
11 |
0 |
27 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4FC0
|
10 |
0 |
0 |
0 |
16 |
0 |
2 |
0 |
0 |
23 |
0 |
0 |
0 |
|
5CSX
|
14 |
0 |
16 |
0 |
16 |
0 |
0 |
0 |
0 |
9 |
0 |
0 |
0 |
|
3TV6
|
14 |
0 |
17 |
0 |
13 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
13 |
|
5CT7
|
15 |
5 |
0 |
0 |
20 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4PP7
|
12 |
0 |
18 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4EHG
|
5 |
5 |
16 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3SKC
|
15 |
0 |
17 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3Q4C
|
15 |
0 |
4 |
0 |
18 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
7 |
|
4KSQ
|
12 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4E26
|
16 |
11 |
22 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4G9C
|
13 |
16 |
5 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
5CSW
|
12 |
6 |
22 |
0 |
16 |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
0 |
|
5HI2
|
12 |
3 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
19 |
0 |
0 |
0 |
|
4G9R
|
16 |
5 |
18 |
0 |
23 |
0 |
0 |
0 |
0 |
12 |
0 |
0 |
0 |
|
4R5Y
|
11 |
0 |
22 |
0 |
17 |
0 |
1 |
0 |
0 |
23 |
0 |
0 |
0 |
|
3PSD
|
17 |
0 |
20 |
0 |
15 |
0 |
4 |
0 |
0 |
7 |
0 |
0 |
0 |
|
4FK3
|
17 |
5 |
16 |
0 |
16 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
|
3PRF
|
14 |
14 |
0 |
0 |
16 |
0 |
13 |
0 |
0 |
0 |
0 |
0 |
0 |
|
1UWH
|
11 |
3 |
0 |
0 |
17 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
16 |
|
5HIE
|
16 |
0 |
29 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4KSP
|
14 |
16 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3OG7
|
15 |
8 |
16 |
0 |
17 |
0 |
3 |
0 |
0 |
21 |
0 |
0 |
10 |
|
3IDP
|
10 |
5 |
0 |
0 |
18 |
0 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3PRI
|
14 |
10 |
0 |
0 |
17 |
0 |
6 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3Q96
|
13 |
0 |
0 |
0 |
21 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3PPK
|
15 |
3 |
31 |
0 |
16 |
0 |
8 |
0 |
0 |
16 |
0 |
0 |
0 |
|
4MNE
|
16 |
3 |
20 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
19 |
|
4H58
|
12 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
|
4XV3
|
14 |
5 |
17 |
0 |
15 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
|
3PPJ
|
15 |
0 |
27 |
0 |
16 |
0 |
2 |
0 |
0 |
17 |
0 |
0 |
0 |
|
4JVG
|
15 |
10 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
6 |
|
4MBJ
|
14 |
3 |
13 |
0 |
19 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
1UWJ
|
13 |
26 |
27 |
0 |
17 |
0 |
6 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3TV4
|
13 |
17 |
18 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4MNF
|
21 |
0 |
12 |
0 |
16 |
0 |
7 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4E4X
|
15 |
0 |
16 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4DBN
|
14 |
0 |
12 |
0 |
15 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
|
5C9C
|
15 |
3 |
4 |
0 |
20 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3II5
|
10 |
14 |
19 |
0 |
19 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
|
3PSB
|
16 |
0 |
18 |
0 |
14 |
0 |
2 |
0 |
0 |
14 |
0 |
0 |
0 |
|
4EHE
|
14 |
0 |
16 |
0 |
18 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
5HID
|
13 |
6 |
3 |
0 |
16 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
|
3C4C
|
16 |
3 |
16 |
0 |
29 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
|
4XV1
|
14 |
0 |
20 |
0 |
15 |
0 |
0 |
10 |
0 |
0 |
0 |
0 |
0 |
|
3D4Q
|
14 |
16 |
13 |
0 |
20 |
0 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |