Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

PDB Details

PDB ID
3EMG
Status
CURRENT
Deposition Date
2008-09-24
Modification Date
2008-12-02
Pubmed ID
18938080
Method
X-RAY DIFFRACTION
Resolution (Å)
2.6
UniProt Accessions
P43405

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C PDIG 4 10
A C EDI 8 3
A N ATP 1 14
A N DFG 4 9
A N ATP 5 5
A N MPP 7 4

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Legend

Color Name Hit Count