Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189

PDB Details

PDB ID
3MY0
Status
CURRENT
Deposition Date
2010-05-08
Modification Date
2015-04-01
Pubmed ID
25557927
Method
X-RAY DIFFRACTION
Resolution (Å)
2.65
UniProt Accessions
P37023

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C AAS 0 18
A C AAS 4 11
A N DFG 1 17
A N ATP 2 16
A N ATP 4 14
A N MPP 5 7
B C AAS 1 14
B C EDI 2 12
B C AAS 6 7
B C AAS 8 4
B N DFG 0 18
B N ATP 1 15
B N ATP 2 15
B N MPP 7 3
B N MT3 8 1
C C AAS 0 20
C N DFG 0 19
C N ATP 2 16
C N ATP 3 16
C N MPP 5 9
D C AAS 0 17
D C EDI 4 11
D C AAS 6 8
D N ATP 1 17
D N DFG 2 17
D N ATP 4 14
D N MPP 5 6
D N MT3 7 2
E C EDI 0 14
E C AAS 2 13
E C AAS 8 5
E C LBP 9 5
E N DFG 0 23
E N ATP 2 16
E N ATP 4 15
E N MT3 5 3
E N MPP 6 3
F N DFG 0 21
F N ATP 1 17
F N ATP 3 16
F N MPP 5 6
F N ATP 7 2
G C AAS 3 12
G C AAS 5 11
G C LBP 8 4
G N DFG 0 19
G N ATP 2 16
G N ATP 3 14
G N MPP 4 10
G N MPP 5 7
G N MT3 7 3
H C AAS 0 28
H C AAS 7 5
H N DFG 0 21
H N ATP 1 16
H N ATP 2 16
H N MPP 6 5
I C EDI 4 12
I C AAS 6 9
I N DFG 1 18
I N ATP 2 16
I N ATP 4 14
I N MPP 5 6
I N MT3 8 1
J C AAS 0 21
J C EDI 2 15
J N ATP 0 16
J N ATP 1 16
J N DFG 3 16
J N MPP 4 15
J N MT3 6 2
K C AAS 2 14
K C AAS 5 8
K C EDI 7 7
K N DFG 0 20
K N ATP 2 16
K N ATP 3 15
K N MT3 7 2
L C AAS 0 22
L C EDI 2 14
L N ATP 0 22
L N DFG 1 20
L N MPP 3 12
L N ATP 4 9
L N MT3 8 1
M C EDI 0 15
M C AAS 1 15
M C AAS 5 10
M C LBP 8 2
M N ATP 0 17
M N ATP 1 17
M N MPP 2 16
M N DFG 5 8
N C AAS 0 19
N C EDI 3 11
N C AAS 8 4
N N ATP 1 18
N N DFG 2 17
N N ATP 4 13
N N MPP 5 4
N N MT3 9 1
O C AAS 1 14
O C AAS 6 8
O C AAS 7 6
O N ATP 0 16
O N ATP 2 15
O N DFG 3 14
O N MPP 7 4
O N MT3 8 2
P C DEF 0 19
P C LBP 4 9
P C AAS 7 4
P N DFG 0 21
P N ATP 1 17
P N ATP 3 15
P N MPP 8 3
Q C LBP 8 4
Q N ATP 0 30
Q N DFG 2 18
Q N MPP 4 8
Q N MT3 5 2
R C AAS 4 12
R C AAS 5 11
R C AAS 6 8
R C LBP 7 4
R N DFG 0 22
R N ATP 2 18
R N ATP 3 13
R N MPP 5 7
R N MPP 7 2
R N MT3 8 1
S C AAS 0 17
S C AAS 2 13
S C DRS 8 3
S N ATP 0 30
S N DFG 3 14
S N MPP 4 7
T C AAS 0 18
T C EDI 2 16
T C AAS 6 3
T N DFG 0 18
T N ATP 3 14
T N ATP 4 11
T N MPP 5 9
T N MT3 6 4
U C EDI 2 12
U C AAS 5 9
U C LBP 6 7
U N DFG 0 22
U N ATP 1 18
U N ATP 3 15
U N MPP 4 9
U N MT3 6 2
U N ATP 7 2
V C AAS 1 15
V C EDI 3 11
V C AAS 6 10
V N ATP 0 31
V N DFG 1 22
V N MPP 3 13
V N MT3 6 2
W C AAS 0 18
W C AAS 2 15
W C LBP 7 4
W N ATP 0 21
W N DFG 1 21
W N MPP 3 13
W N ATP 4 11
W N MT3 7 1
X C CMP 4 10
X C AAS 5 8
X C LBP 11 2
X N ATP 0 20
X N DFG 1 16
X N MPP 2 15
X N ATP 4 11
X N MT3 8 1

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