- Protein Name
- Serine/threonine-protein kinase receptor R3
- Gene Name
- ACVRL1
- Organism
-
Homo sapiens
- Function
- Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
| EDI |
16 |
7 |
12.0 |
| MT3 |
4 |
1 |
2.0 |
| ATP |
31 |
2 |
16.0 |
| DEF |
19 |
19 |
19.0 |
| DRS |
3 |
3 |
3.0 |
| AAS |
28 |
3 |
11.5 |
| MPP |
16 |
2 |
7.0 |
| DFG |
23 |
8 |
18.0 |
| LBP |
9 |
2 |
4.0 |
| CMP |
10 |
10 |
10.0 |
| 1 |
0 |
0 |
1 |
1 |
0 |
1 |
1 |
2 |
0 |
0 |
0 |
0 |
|
3MY0
|
16 |
4 |
0 |
31 |
19 |
3 |
28 |
16 |
23 |
9 |
10 |
0 |
0 |
|
AFP37023
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
0 |