Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidinone-based Inhibitor

PDB Details

PDB ID
4E4X
Status
CURRENT
Deposition Date
2012-03-13
Modification Date
2012-05-23
Pubmed ID
22534450
Method
X-RAY DIFFRACTION
Resolution (Å)
3.6
UniProt Accessions
P15056

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C DFG 6 6
A N ATP 1 16
A N MT3 2 16
A N ATP 3 14
A N MPP 4 14
A N MT3 7 3
A N MT3 8 2
B N ATP 0 17
B N MT3 1 16
B N ATP 2 16
B N MPP 4 15
B N MT3 9 2

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Legend

Color Name Hit Count