Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib

PDB Details

PDB ID
4I22
Status
CURRENT
Deposition Date
2012-11-21
Modification Date
2014-10-15
Pubmed ID
23273428
Method
X-RAY DIFFRACTION
Resolution (Å)
1.71
UniProt Accessions
P00533

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 5 12
A C DRS 6 4
A C PDIG 7 3
A N MT3 0 18
A N ATP 1 16
A N MPP 2 16
A N DFG 3 13
A N MPP 4 9
A N MT3 8 2

Mapping Results Viewer

Use your mouse to drag, rotate, and zoom. Select structure to view on the right using dropdown.
Powered by NGL

Legend

Color Name Hit Count