P00533

Background

Protein Name
Epidermal growth factor receptor
Gene Name
EGFR
Organism
Homo sapiens

Annotations

Function
Isoform 2 may act as an antagonist of EGF action. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MT3 32 1 16.0
ATP 27 1 11.0
MPP 25 1 7.0
PIF 18 2 11.5
DFG 16 2 9.5
EDI 16 2 11.0
CMP 17 2 11.0
PDIG 13 2 6.5
DRS 17 2 4.0
LBP 10 2 2.0
DEF 2 2 2.0

Mapping Results

PDB ID Maximum Consensus Site Population
MT3 site ATP site MPP site PIF site DFG site EDI site CMP site PDIG site DRS site PMP site LBP site AAS site DEF site
Total Druggable Structures per Site 33 49 30 3 4 2 3 0 6 0 0 0 0
3UG1 0 11 18 0 0 10 0 0 2 0 0 0 0
4I1Z 18 11 19 0 0 0 6 2 8 0 0 0 0
5HG7 18 12 0 16 0 10 0 0 0 0 0 0 0
2EB2 0 18 16 0 6 0 17 12 0 0 2 0 0
4R3R 0 0 0 0 0 13 0 0 0 0 0 0 0
5HIB 0 7 0 0 0 14 0 0 0 0 0 0 0
3IKA 24 15 16 0 15 5 2 8 16 0 2 0 0
3LZB 20 3 10 0 0 4 0 13 13 0 0 0 0
5CNN 19 16 16 0 0 0 0 8 17 0 0 0 0
5EDQ 0 0 19 0 0 11 0 0 2 0 0 0 0
5CAQ 0 2 11 0 6 13 0 0 2 0 0 0 0
3UG2 0 14 5 0 0 6 12 0 0 0 0 0 0
2GS2 0 16 0 0 5 0 13 0 0 0 3 0 0
2EB3 0 17 21 0 8 0 16 0 0 0 0 0 0
5C8K 0 0 6 0 11 15 12 0 2 0 0 0 0
5EM8 0 3 5 0 0 15 0 0 3 0 0 0 0
1XKK 16 13 5 0 0 5 3 4 5 0 0 0 0
5FEE 0 7 9 0 0 5 0 0 0 0 0 0 0
5CAL 0 9 9 0 11 14 11 0 2 0 0 0 0
4ZSE 20 0 17 0 0 13 0 10 16 0 0 0 0
4TKS 0 19 17 0 11 11 0 0 0 0 0 0 0
5CAV 0 18 24 0 9 11 0 0 0 0 0 0 0
5HG5 16 6 9 13 0 0 0 2 0 0 0 0 0
3W2Q 0 13 2 0 0 13 0 0 0 0 0 0 0
4RJ7 0 16 22 0 10 11 0 0 2 0 0 0 0
4HJO 23 16 7 13 0 0 0 6 0 0 0 0 0
5HG8 15 12 17 8 0 0 0 0 4 0 0 0 0
1M17 0 18 18 0 12 7 12 0 7 0 0 0 0
4WD5 0 0 11 14 15 0 0 0 0 0 4 0 0
2JIU 14 15 16 0 15 0 0 8 10 0 0 0 0
4WKQ 0 13 10 0 5 12 0 0 0 0 0 0 0
2RFD 23 15 18 18 0 7 11 6 0 0 0 0 0
2JIV 16 18 15 7 0 0 2 10 0 0 0 0 0
3W2S 18 12 2 0 0 8 12 5 3 0 0 0 0
5CAP 0 8 10 0 0 10 0 0 2 0 0 0 0
4G5J 0 16 19 0 3 0 9 0 14 0 0 0 0
4RJ8 0 20 12 0 11 15 13 0 0 0 0 0 0
2ITV 0 15 18 0 0 14 10 0 7 0 0 0 0
5C8M 0 0 6 0 4 12 0 10 10 0 0 0 0
4I21 17 7 8 5 0 2 0 0 2 0 8 0 0
5CAS 0 27 7 0 9 13 14 0 2 0 0 0 0
AFP00533 0 16 0 0 16 0 0 3 0 0 0 0 0
2ITX 0 16 5 0 0 0 0 0 0 0 0 0 0
2ITZ 0 17 0 0 5 12 9 0 7 0 0 0 0
4LRM 0 14 0 0 12 14 6 0 17 0 0 0 0
3W2P 0 3 0 0 0 6 0 0 0 0 0 0 0
3GOP 16 14 0 0 0 6 0 2 10 0 0 0 0
3VJO 0 17 3 0 0 10 0 7 0 0 2 0 0
2ITT 0 19 6 0 16 11 0 0 6 0 0 0 0
2ITP 0 20 5 0 8 8 0 0 0 0 0 0 0
5CAN 0 0 8 0 8 14 0 0 2 0 0 0 0
4LL0 2 17 18 0 0 0 0 11 0 0 0 0 0
3GT8 18 16 17 4 0 10 11 9 17 0 0 0 0
5CNO 22 14 16 0 0 0 0 13 0 0 0 0 0
3BEL 19 0 0 0 0 3 0 3 13 0 0 0 0
4JQ8 0 20 5 0 10 11 0 0 0 0 0 0 0
4RJ5 0 23 11 0 5 16 0 0 4 0 0 0 0
2ITN 0 15 0 0 0 11 11 0 0 0 0 0 0
4R3P 0 15 11 0 0 0 0 0 3 0 3 0 0
3W2R 32 15 0 6 0 6 0 5 15 0 0 0 0
2ITO 0 21 11 0 2 10 0 0 0 0 0 0 0
4I24 19 17 15 2 15 5 12 8 17 0 0 0 0
4I22 18 16 16 0 13 12 0 3 4 0 0 0 0
4LI5 0 14 15 0 10 0 0 0 0 0 0 0 0
4WRG 0 17 3 0 0 13 0 0 0 0 0 0 0
2J5E 0 15 5 0 5 2 0 0 0 0 0 0 0
2GS6 0 19 8 0 0 0 0 4 0 0 10 0 0
2RFE 22 16 7 12 0 2 2 10 0 0 0 0 0
5EM5 0 16 4 0 3 12 0 0 7 0 0 0 0
5EDP 0 0 21 0 2 15 0 0 0 0 0 0 0
5FEQ 0 5 6 0 0 0 16 0 0 0 0 0 0
4ZAU 0 17 10 0 5 13 0 0 0 0 0 0 0
5EDR 0 0 3 0 4 11 0 0 3 0 0 0 0
5CZH 0 17 18 0 5 13 0 0 0 0 0 0 0
2JIT 16 12 25 0 15 10 0 4 6 0 6 0 0
4R5S 26 4 8 0 0 6 2 10 5 0 0 0 0
5HIC 0 2 11 0 11 15 0 0 2 0 0 0 0
4RJ4 0 26 10 0 13 14 0 0 0 0 0 0 0
2ITY 0 20 12 0 16 12 0 0 0 0 0 0 0
2J6M 0 16 0 0 2 0 0 0 0 0 2 0 0
4JRV 0 19 17 0 12 7 0 0 0 0 0 0 0
5HG9 0 17 15 0 6 5 0 8 2 0 0 0 0
4JQ7 0 16 6 0 11 11 0 0 0 0 0 0 0
4RJ6 0 22 8 0 14 11 0 0 3 0 0 0 0
3VJN 0 2 4 0 6 6 0 0 0 0 0 0 0
4G5P 20 11 0 0 16 11 0 2 14 0 4 0 0
4JR3 0 19 0 12 9 13 0 0 0 0 2 0 0
4I20 25 0 17 0 0 0 0 0 0 0 4 0 0
5FED 0 12 8 0 0 11 0 0 2 0 8 0 0
3POZ 16 14 0 0 0 0 11 2 5 0 0 0 0
2J5F 0 17 22 0 13 6 0 0 0 0 0 0 0
3W32 16 14 5 0 0 0 0 7 0 0 0 0 0
5CAU 0 3 9 0 13 13 10 0 0 0 0 0 0
1M14 0 16 0 0 2 14 0 0 0 0 0 0 0
2ITQ 0 19 4 0 0 10 0 0 2 0 0 0 0
5CZI 0 10 17 0 2 8 0 0 0 0 2 0 0
5EM7 0 7 5 0 4 14 0 0 2 0 0 0 0
2ITU 0 14 0 0 0 14 0 0 4 0 0 0 0
5CAO 6 8 9 0 10 15 0 0 0 0 0 0 0
3W2O 0 0 17 0 0 0 0 0 3 0 0 0 2
5D41 17 17 16 0 0 16 0 0 9 0 0 0 0
5EM6 0 7 3 0 0 15 0 0 2 0 0 0 0
4ZJV 20 12 4 0 0 9 0 0 0 0 0 0 0
2GS7 21 15 9 16 0 0 0 8 3 0 0 0 0
2RF9 18 6 15 14 6 3 0 2 15 0 2 0 0
4LQM 0 17 13 0 6 12 0 0 0 0 0 0 0
2ITW 0 17 3 0 9 5 0 0 0 0 0 0 0
2RGP 19 18 2 0 0 0 10 3 14 0 0 0 0
5C8N 0 23 8 0 13 8 13 0 2 0 0 0 0
4I23 0 18 0 0 0 0 0 4 0 0 0 0 0
3W33 20 15 2 0 0 9 7 9 0 0 0 0 0