Structure of T790M EGFR kinase domain co-crystallized with dacomitinib

PDB Details

PDB ID
4I24
Status
CURRENT
Deposition Date
2012-11-21
Modification Date
2013-02-27
Pubmed ID
23273428
Method
X-RAY DIFFRACTION
Resolution (Å)
1.8
UniProt Accessions
P00533

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C DRS 2 15
A C DRS 6 5
A C EDI 7 5
A N ATP 0 17
A N MPP 1 15
A N MT3 2 15
A N MT3 3 14
A N MPP 5 10
A N MPP 6 4
B C DRS 1 17
B C CMP 4 12
B C PDIG 5 8
B C DRS 7 2
B C CMP 9 2
B N MT3 0 19
B N MPP 1 15
B N ATP 2 15
B N DFG 3 15
B N MPP 4 7
B N MT3 6 4
B N MPP 8 3
B N MT3 9 3
B N PIF 11 2

Mapping Results Viewer

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Legend

Color Name Hit Count