Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

PDB Details

PDB ID
4WHZ
Status
CURRENT
Deposition Date
2014-09-24
Modification Date
2014-12-31
Pubmed ID
25393557
Method
X-RAY DIFFRACTION
Resolution (Å)
1.79
UniProt Accessions
P53779

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 1 15
A C DEF 2 14
A C EDI 5 7
A C DFG 6 7
A C CMP 7 5
A C PDIG 8 4
A C DRS 11 2
A N ATP 0 20
A N ATP 1 17
A N PIF 2 16
A N PIF 3 14
A N DFG 4 10
A N MT3 6 4
A N ATP 7 3

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Legend

Color Name Hit Count