- Protein Name
- Mitogen-activated protein kinase 10
- Gene Name
- MAPK10
- Organism
-
Homo sapiens
- Function
- Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
2 |
2 |
2.0 |
| AAS |
13 |
4 |
8.5 |
| MT3 |
18 |
2 |
9.0 |
| ATP |
34 |
1 |
15.0 |
| DEF |
16 |
6 |
14.0 |
| DFG |
14 |
3 |
8.0 |
| CMP |
13 |
2 |
5.0 |
| EDI |
26 |
3 |
18.0 |
| DRS |
13 |
2 |
7.0 |
| PDIG |
24 |
1 |
5.0 |
| PIF |
24 |
13 |
16.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
6 |
0 |
30 |
14 |
0 |
0 |
0 |
40 |
0 |
19 |
41 |
|
2ZDU
|
0 |
0 |
15 |
0 |
16 |
16 |
0 |
5 |
0 |
19 |
13 |
0 |
16 |
|
2R9S
|
0 |
0 |
15 |
0 |
18 |
12 |
7 |
0 |
0 |
18 |
7 |
14 |
16 |
|
4Z9L
|
0 |
0 |
0 |
0 |
16 |
14 |
8 |
10 |
0 |
26 |
13 |
10 |
16 |
|
2B1P
|
0 |
0 |
0 |
0 |
15 |
12 |
4 |
13 |
0 |
16 |
0 |
12 |
16 |
|
4Y46
|
0 |
0 |
14 |
0 |
20 |
14 |
0 |
0 |
0 |
21 |
0 |
19 |
18 |
|
2EXC
|
0 |
0 |
0 |
0 |
15 |
15 |
11 |
0 |
0 |
18 |
13 |
17 |
17 |
|
2ZDT
|
0 |
0 |
14 |
0 |
13 |
13 |
0 |
0 |
0 |
24 |
12 |
19 |
16 |
|
3FI2
|
0 |
0 |
0 |
0 |
13 |
16 |
0 |
0 |
0 |
22 |
6 |
0 |
0 |
|
3TTJ
|
0 |
0 |
2 |
0 |
16 |
14 |
14 |
0 |
0 |
17 |
4 |
2 |
16 |
|
1PMU
|
0 |
0 |
0 |
0 |
34 |
10 |
9 |
0 |
0 |
18 |
0 |
20 |
17 |
|
2WAJ
|
0 |
0 |
0 |
0 |
16 |
16 |
8 |
0 |
0 |
23 |
5 |
0 |
17 |
|
3KVX
|
0 |
0 |
14 |
0 |
16 |
12 |
0 |
0 |
0 |
18 |
11 |
15 |
16 |
|
4KKG
|
0 |
0 |
16 |
0 |
17 |
16 |
0 |
6 |
0 |
19 |
6 |
16 |
17 |
|
1PMV
|
0 |
0 |
2 |
0 |
21 |
7 |
0 |
0 |
0 |
24 |
9 |
5 |
17 |
|
4H3B
|
0 |
4 |
7 |
0 |
16 |
16 |
9 |
0 |
0 |
25 |
10 |
16 |
16 |
|
4X21
|
0 |
0 |
13 |
0 |
19 |
10 |
0 |
0 |
0 |
25 |
0 |
11 |
17 |
|
3V6S
|
0 |
13 |
10 |
0 |
16 |
11 |
0 |
5 |
0 |
21 |
3 |
2 |
18 |
|
3FI3
|
0 |
0 |
0 |
0 |
15 |
8 |
0 |
0 |
0 |
22 |
7 |
20 |
24 |
|
4H39
|
0 |
0 |
4 |
0 |
17 |
0 |
5 |
4 |
0 |
25 |
11 |
10 |
16 |
|
3OY1
|
0 |
0 |
0 |
0 |
16 |
13 |
8 |
0 |
0 |
19 |
0 |
20 |
18 |
|
1JNK
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2P33
|
0 |
0 |
14 |
0 |
20 |
16 |
0 |
4 |
0 |
20 |
8 |
4 |
19 |
|
4Y5H
|
0 |
0 |
17 |
0 |
28 |
15 |
0 |
5 |
0 |
19 |
0 |
0 |
19 |
|
4W4X
|
0 |
0 |
8 |
0 |
11 |
15 |
0 |
0 |
0 |
15 |
5 |
3 |
16 |
|
4W4V
|
0 |
0 |
10 |
0 |
15 |
14 |
3 |
7 |
0 |
25 |
4 |
3 |
16 |
|
1PMN
|
0 |
0 |
5 |
0 |
15 |
12 |
14 |
4 |
0 |
17 |
10 |
21 |
17 |
|
3G9N
|
0 |
0 |
0 |
0 |
13 |
16 |
8 |
0 |
0 |
10 |
8 |
16 |
13 |
|
3OXI
|
0 |
0 |
13 |
0 |
18 |
16 |
0 |
0 |
0 |
25 |
8 |
20 |
16 |
|
2O2U
|
0 |
0 |
0 |
0 |
13 |
16 |
0 |
8 |
0 |
15 |
0 |
21 |
18 |
|
4H36
|
0 |
0 |
2 |
0 |
12 |
16 |
6 |
5 |
0 |
25 |
8 |
13 |
15 |
|
4U79
|
0 |
0 |
2 |
0 |
13 |
14 |
0 |
0 |
0 |
24 |
8 |
17 |
19 |
|
3FV8
|
0 |
0 |
0 |
0 |
16 |
13 |
0 |
0 |
0 |
22 |
6 |
17 |
0 |
|
3G9L
|
0 |
0 |
0 |
0 |
16 |
15 |
7 |
0 |
0 |
20 |
2 |
1 |
17 |
|
3CGO
|
0 |
0 |
17 |
0 |
18 |
14 |
0 |
6 |
0 |
15 |
11 |
24 |
16 |
|
4KKH
|
0 |
0 |
2 |
0 |
16 |
14 |
13 |
5 |
0 |
16 |
3 |
2 |
21 |
|
3G90
|
0 |
0 |
17 |
0 |
18 |
14 |
0 |
0 |
0 |
20 |
3 |
20 |
15 |
|
4KKE
|
0 |
0 |
10 |
0 |
17 |
13 |
0 |
0 |
0 |
24 |
9 |
14 |
17 |
|
3CGF
|
0 |
0 |
16 |
0 |
18 |
13 |
0 |
0 |
0 |
20 |
2 |
21 |
19 |
|
2OK1
|
0 |
0 |
15 |
0 |
18 |
6 |
0 |
0 |
0 |
17 |
0 |
3 |
18 |
|
2O0U
|
0 |
0 |
18 |
0 |
17 |
16 |
7 |
0 |
0 |
19 |
0 |
6 |
16 |
|
3TTI
|
0 |
0 |
0 |
0 |
17 |
14 |
9 |
0 |
0 |
24 |
4 |
15 |
17 |
|
3V6R
|
0 |
0 |
10 |
0 |
15 |
6 |
0 |
5 |
0 |
24 |
10 |
18 |
18 |
|
4WHZ
|
0 |
0 |
4 |
0 |
20 |
14 |
10 |
5 |
0 |
15 |
2 |
4 |
16 |
|
4W4Y
|
0 |
0 |
0 |
0 |
12 |
13 |
0 |
0 |
0 |
13 |
3 |
3 |
17 |
|
3PTG
|
2 |
0 |
9 |
0 |
14 |
16 |
0 |
0 |
0 |
16 |
10 |
20 |
16 |
|
3RTP
|
0 |
0 |
0 |
0 |
19 |
16 |
0 |
0 |
0 |
15 |
4 |
2 |
17 |
|
3DA6
|
0 |
0 |
11 |
0 |
12 |
16 |
7 |
0 |
0 |
18 |
12 |
3 |
15 |
|
4W4W
|
0 |
0 |
2 |
0 |
15 |
14 |
13 |
2 |
0 |
24 |
6 |
2 |
16 |