(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors

PDB Details

PDB ID
4YMJ
Status
CURRENT
Deposition Date
2015-03-06
Modification Date
2015-06-03
Pubmed ID
26005534
Method
X-RAY DIFFRACTION
Resolution (Å)
2.0
UniProt Accessions
Q16288

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C DFG 4 10
A C ATP 10 2
A N PIF 0 19
A N ATP 1 17
A N PIF 5 9
A N MT3 6 9

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Legend

Color Name Hit Count