- Protein Name
- NT-3 growth factor receptor
- Gene Name
- NTRK3
- Organism
-
Homo sapiens
- Function
- Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
8 |
6 |
8.0 |
| PIF |
19 |
4 |
8.0 |
| EDI |
17 |
10 |
13.5 |
| MT3 |
12 |
2 |
8.5 |
| ATP |
17 |
4 |
15.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
1 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
|
4YMJ
|
0 |
0 |
19 |
0 |
0 |
0 |
9 |
0 |
0 |
0 |
0 |
17 |
0 |
|
3V5Q
|
8 |
0 |
7 |
0 |
0 |
17 |
12 |
0 |
0 |
0 |
0 |
16 |
0 |