The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a highly potent and selective inhibitor of RIP2 Kinase, Compound 3 complex

PDB Details

PDB ID
5J79
Status
CURRENT
Deposition Date
2016-04-06
Modification Date
2016-06-08
Pubmed ID
27109867
Method
X-RAY DIFFRACTION
Resolution (Å)
2.69
UniProt Accessions
O43353

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 1 15
A C CMP 4 11
A C AAS 5 10
A C DRS 7 4
A C DRS 9 2
A N ATP 1 15
A N ATP 2 14
A N ATP 7 5
A N MPP 9 3

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Legend

Color Name Hit Count