- Protein Name
- Receptor-interacting serine/threonine-protein kinase 2
- Gene Name
- RIPK2
- Organism
-
Homo sapiens
- Function
- Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
12 |
1 |
5.0 |
| DFG |
15 |
2 |
2.0 |
| DRS |
14 |
2 |
5.5 |
| EDI |
15 |
8 |
9.5 |
| MT3 |
15 |
6 |
10.5 |
| AAS |
14 |
3 |
10.0 |
| CMP |
15 |
3 |
8.5 |
| ATP |
29 |
4 |
15.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
7 |
0 |
|
5AR3
|
7 |
2 |
0 |
12 |
0 |
0 |
0 |
0 |
0 |
12 |
0 |
17 |
0 |
|
5AR2
|
7 |
0 |
0 |
8 |
0 |
8 |
0 |
0 |
0 |
5 |
0 |
25 |
0 |
|
5J79
|
3 |
0 |
0 |
4 |
0 |
15 |
0 |
10 |
0 |
11 |
0 |
15 |
0 |
|
5AR5
|
8 |
2 |
0 |
7 |
0 |
8 |
0 |
0 |
0 |
15 |
0 |
15 |
0 |
|
5AR4
|
5 |
2 |
0 |
5 |
0 |
10 |
0 |
0 |
0 |
8 |
0 |
18 |
0 |
|
AFO43353
|
0 |
15 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4C8B
|
8 |
0 |
0 |
14 |
0 |
0 |
7 |
14 |
0 |
9 |
0 |
27 |
0 |
|
5AR8
|
5 |
0 |
0 |
5 |
0 |
0 |
15 |
0 |
0 |
3 |
0 |
17 |
0 |
|
5AR7
|
5 |
0 |
0 |
4 |
0 |
13 |
0 |
3 |
0 |
11 |
0 |
29 |
0 |
|
5J7B
|
12 |
0 |
0 |
8 |
0 |
9 |
14 |
0 |
0 |
8 |
0 |
18 |
0 |