- Protein Name
- Hepatocyte growth factor receptor
- Gene Name
- MET
- Organism
-
Homo sapiens
- Function
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).
Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
28 |
1 |
10.0 |
| AAS |
17 |
5 |
14.0 |
| MT3 |
25 |
2 |
14.0 |
| ATP |
25 |
1 |
9.0 |
| DFG |
4 |
2 |
2.0 |
| CMP |
20 |
2 |
11.0 |
| EDI |
18 |
4 |
14.0 |
| DRS |
21 |
2 |
10.0 |
| PDIG |
2 |
2 |
2.0 |
| PIF |
23 |
2 |
10.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
13 |
1 |
27 |
0 |
13 |
0 |
0 |
1 |
0 |
8 |
13 |
0 |
4 |
|
3Q6U
|
13 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
3 |
0 |
16 |
|
3ZC5
|
10 |
0 |
14 |
0 |
21 |
0 |
0 |
0 |
0 |
15 |
6 |
0 |
0 |
|
2RFN
|
25 |
0 |
16 |
0 |
18 |
0 |
0 |
13 |
0 |
17 |
7 |
0 |
0 |
|
3ZZE
|
11 |
0 |
11 |
0 |
10 |
0 |
0 |
0 |
0 |
14 |
3 |
0 |
0 |
|
3CTJ
|
18 |
0 |
7 |
0 |
12 |
0 |
2 |
0 |
0 |
0 |
18 |
0 |
0 |
|
2WKM
|
10 |
0 |
17 |
0 |
9 |
0 |
0 |
0 |
0 |
10 |
2 |
0 |
0 |
|
4DEH
|
11 |
0 |
16 |
0 |
11 |
0 |
0 |
0 |
0 |
0 |
11 |
0 |
0 |
|
3Q6W
|
16 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
7 |
0 |
0 |
|
4R1V
|
8 |
0 |
21 |
0 |
0 |
0 |
0 |
0 |
0 |
14 |
6 |
0 |
0 |
|
4IWD
|
18 |
0 |
0 |
0 |
4 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
|
4R1Y
|
6 |
0 |
15 |
0 |
16 |
0 |
0 |
0 |
0 |
14 |
7 |
0 |
7 |
|
4XYF
|
9 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3F82
|
0 |
0 |
14 |
0 |
16 |
0 |
4 |
0 |
0 |
4 |
16 |
0 |
0 |
|
3ZBX
|
0 |
0 |
15 |
0 |
9 |
0 |
0 |
0 |
0 |
15 |
9 |
0 |
0 |
|
3CE3
|
8 |
0 |
12 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
14 |
0 |
0 |
|
3DKC
|
17 |
0 |
18 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
|
AFP08581
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4MXC
|
10 |
0 |
14 |
0 |
12 |
0 |
0 |
20 |
0 |
13 |
10 |
0 |
0 |
|
3CD8
|
10 |
0 |
16 |
0 |
13 |
0 |
0 |
0 |
0 |
7 |
13 |
0 |
12 |
|
3I5N
|
18 |
0 |
7 |
0 |
12 |
0 |
0 |
0 |
0 |
0 |
13 |
0 |
0 |
|
3RHK
|
15 |
0 |
12 |
0 |
10 |
0 |
0 |
0 |
0 |
12 |
3 |
0 |
0 |
|
3DKF
|
8 |
0 |
0 |
0 |
9 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
|
3ZCL
|
12 |
0 |
12 |
0 |
21 |
0 |
0 |
0 |
0 |
14 |
8 |
0 |
0 |
|
3R7O
|
9 |
0 |
0 |
0 |
2 |
0 |
2 |
0 |
0 |
0 |
2 |
0 |
0 |
|
4DEG
|
9 |
0 |
16 |
0 |
11 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
|
1R0P
|
2 |
0 |
0 |
0 |
5 |
0 |
0 |
0 |
0 |
12 |
16 |
0 |
0 |
|
2WGJ
|
0 |
0 |
19 |
0 |
21 |
0 |
0 |
0 |
0 |
12 |
5 |
0 |
0 |
|
3VW8
|
6 |
0 |
8 |
0 |
4 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
|
3C1X
|
0 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |
9 |
|
3LQ8
|
9 |
0 |
16 |
0 |
8 |
0 |
2 |
0 |
0 |
13 |
13 |
0 |
0 |
|
3EFK
|
17 |
0 |
16 |
0 |
19 |
0 |
0 |
0 |
0 |
16 |
21 |
0 |
0 |
|
5EYD
|
3 |
0 |
25 |
0 |
8 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4KNB
|
12 |
0 |
23 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
2 |
0 |
12 |
|
4XMO
|
6 |
0 |
16 |
0 |
7 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2WD1
|
9 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
11 |
0 |
0 |
|
3L8V
|
4 |
0 |
15 |
0 |
7 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
|
3DKG
|
24 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
|
3ZXZ
|
3 |
0 |
18 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
23 |
|
4GG7
|
16 |
0 |
0 |
0 |
8 |
0 |
0 |
0 |
0 |
11 |
7 |
0 |
18 |
|
4EEV
|
9 |
13 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
15 |
0 |
0 |
|
3F66
|
13 |
0 |
18 |
0 |
13 |
0 |
0 |
0 |
0 |
0 |
20 |
0 |
19 |
|
4DEI
|
28 |
0 |
16 |
0 |
12 |
0 |
0 |
0 |
0 |
12 |
12 |
0 |
0 |
|
2RFS
|
7 |
0 |
22 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
2 |
|
3A4P
|
26 |
0 |
17 |
0 |
9 |
0 |
0 |
0 |
0 |
0 |
13 |
0 |
0 |
|
3EFJ
|
26 |
0 |
17 |
0 |
19 |
0 |
0 |
11 |
0 |
16 |
14 |
2 |
0 |
|
3U6H
|
6 |
0 |
14 |
0 |
25 |
0 |
0 |
0 |
0 |
15 |
17 |
0 |
0 |
|
3U6I
|
4 |
0 |
17 |
0 |
24 |
0 |
0 |
0 |
0 |
18 |
15 |
0 |
0 |
|
3CTH
|
5 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
15 |
|
1R1W
|
0 |
0 |
0 |
0 |
5 |
0 |
0 |
0 |
0 |
10 |
17 |
0 |
0 |
|
3QTI
|
11 |
17 |
17 |
0 |
18 |
0 |
0 |
8 |
0 |
0 |
15 |
0 |
0 |
|
5EYC
|
11 |
0 |
16 |
0 |
6 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4AOI
|
2 |
0 |
16 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2G15
|
10 |
0 |
16 |
0 |
5 |
0 |
0 |
0 |
0 |
9 |
2 |
0 |
7 |
|
4AP7
|
0 |
0 |
15 |
0 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3CCN
|
26 |
0 |
23 |
0 |
19 |
0 |
0 |
0 |
0 |
0 |
12 |
0 |
3 |
|
4GG5
|
15 |
0 |
0 |
0 |
8 |
0 |
0 |
2 |
0 |
15 |
2 |
0 |
12 |