- Protein Name
- Tyrosine-protein kinase HCK
- Gene Name
- HCK
- Organism
-
Homo sapiens
- Function
- Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
18 |
13 |
16.0 |
| DFG |
16 |
1 |
12.0 |
| PIF |
12 |
12 |
12.0 |
| EDI |
15 |
3 |
3.0 |
| MT3 |
24 |
2 |
15.0 |
| AAS |
15 |
3 |
10.0 |
| CMP |
5 |
5 |
5.0 |
| PDIG |
15 |
2 |
7.0 |
| ATP |
28 |
2 |
13.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
18 |
1 |
0 |
0 |
0 |
0 |
13 |
0 |
0 |
0 |
0 |
11 |
0 |
|
2HK5
|
13 |
8 |
0 |
0 |
0 |
15 |
2 |
0 |
0 |
0 |
0 |
16 |
0 |
|
3VS2
|
16 |
0 |
0 |
0 |
0 |
0 |
21 |
10 |
0 |
0 |
6 |
23 |
0 |
|
3VS7
|
18 |
0 |
12 |
0 |
0 |
0 |
17 |
3 |
0 |
0 |
13 |
17 |
0 |
|
4LUD
|
16 |
0 |
0 |
0 |
0 |
0 |
18 |
4 |
0 |
0 |
7 |
21 |
0 |
|
2C0I
|
16 |
0 |
0 |
0 |
0 |
3 |
16 |
12 |
0 |
0 |
7 |
11 |
0 |
|
3VS3
|
16 |
13 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
2 |
18 |
0 |
|
2C0O
|
16 |
0 |
0 |
0 |
0 |
3 |
15 |
0 |
0 |
5 |
15 |
15 |
0 |
|
AFP08631
|
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3VS5
|
16 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
3 |
16 |
0 |
|
1AD5
|
16 |
0 |
0 |
0 |
0 |
13 |
24 |
0 |
0 |
0 |
0 |
14 |
0 |
|
2C0T
|
16 |
0 |
0 |
0 |
0 |
3 |
17 |
12 |
0 |
0 |
12 |
16 |
0 |
|
3VS6
|
16 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
0 |
5 |
16 |
0 |
|
3VS4
|
16 |
0 |
0 |
0 |
0 |
0 |
8 |
0 |
0 |
0 |
3 |
14 |
0 |
|
1QCF
|
17 |
0 |
0 |
0 |
0 |
0 |
21 |
0 |
0 |
0 |
0 |
15 |
0 |
|
2HCK
|
16 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
0 |
18 |
0 |
|
3VRZ
|
17 |
0 |
0 |
0 |
0 |
0 |
17 |
11 |
0 |
0 |
13 |
13 |
0 |
|
3VS1
|
16 |
0 |
0 |
0 |
0 |
0 |
19 |
10 |
0 |
0 |
13 |
13 |
0 |
|
3VRY
|
16 |
13 |
0 |
0 |
0 |
0 |
22 |
0 |
0 |
0 |
2 |
28 |
0 |
|
4LUE
|
16 |
0 |
0 |
0 |
0 |
0 |
18 |
15 |
0 |
0 |
14 |
18 |
0 |
|
3VS0
|
16 |
1 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |
0 |
15 |
12 |
0 |