P08631

Background

Protein Name
Tyrosine-protein kinase HCK
Gene Name
HCK
Organism
Homo sapiens

Annotations

Function
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.

Mapping Statistics

Site
Maximum Consensus Site Population
Minimum Consensus Site Population
Median Consensus Site Population
EDI 15 3 3.0
MT3 24 2 15.0
PIF 12 12 12.0
ATP 28 2 13.0
AAS 15 3 10.0
MPP 18 13 16.0
DFG 16 1 12.0
CMP 5 5 5.0
PDIG 15 2 7.0

Mapping Results

PDB ID
Maximum Consensus Site Population
EDI site
MT3 site
PIF site
ATP site
DEF site
DRS site
AAS site
MPP site
DFG site
LBP site
CMP site
PDIG site
PMP site
Total Druggable Structures per Site 0 13 0 11 0 0 0 18 1 0 0 0 0
1AD5 13 24 0 14 0 0 0 16 0 0 0 0 0
1QCF 0 21 0 15 0 0 0 17 0 0 0 0 0
2C0I 3 16 0 11 0 0 12 16 0 0 0 7 0
2C0O 3 15 0 15 0 0 0 16 0 0 5 15 0
2C0T 3 17 0 16 0 0 12 16 0 0 0 12 0
2HCK 0 18 0 18 0 0 0 16 0 0 0 0 0
2HK5 15 2 0 16 0 0 0 13 8 0 0 0 0
3VRY 0 22 0 28 0 0 0 16 13 0 0 2 0
3VRZ 0 17 0 13 0 0 11 17 0 0 0 13 0
3VS0 0 15 0 12 0 0 0 16 1 0 0 15 0
3VS1 0 19 0 13 0 0 10 16 0 0 0 13 0
3VS2 0 21 0 23 0 0 10 16 0 0 0 6 0
3VS3 0 3 0 18 0 0 0 16 13 0 0 2 0
3VS4 0 8 0 14 0 0 0 16 0 0 0 3 0
3VS5 0 16 0 16 0 0 0 16 0 0 0 3 0
3VS6 0 10 0 16 0 0 0 16 0 0 0 5 0
3VS7 0 17 12 17 0 0 3 18 0 0 0 13 0
4LUD 0 18 0 21 0 0 4 16 0 0 0 7 0
4LUE 0 18 0 18 0 0 15 16 0 0 0 14 0
AFP08631 0 0 0 0 0 0 0 0 16 0 0 0 0