- Protein Name
- Receptor-type tyrosine-protein kinase FLT3
- Gene Name
- FLT3
- Organism
-
Homo sapiens
- Function
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
21 |
2 |
12.0 |
| DFG |
4 |
4 |
4.0 |
| MT3 |
21 |
21 |
21.0 |
| AAS |
2 |
2 |
2.0 |
| CMP |
8 |
8 |
8.0 |
| PDIG |
2 |
2 |
2.0 |
| ATP |
18 |
13 |
15.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
3 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
2 |
0 |
|
4XUF
|
13 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
18 |
0 |
|
1RJB
|
19 |
0 |
0 |
0 |
0 |
0 |
21 |
0 |
0 |
8 |
0 |
13 |
0 |
|
AFP36888
|
21 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4RT7
|
19 |
4 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
17 |
0 |