- Protein Name
- Aurora kinase A
- Gene Name
- Aurka
- Organism
-
Mus musculus
- Function
- Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
27 |
17 |
20.0 |
| AAS |
26 |
2 |
11.5 |
| MT3 |
21 |
3 |
12.0 |
| ATP |
19 |
1 |
16.0 |
| CMP |
15 |
4 |
11.0 |
| EDI |
6 |
2 |
4.5 |
| PDIG |
29 |
1 |
12.0 |
| PIF |
20 |
8 |
16.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
8 |
3 |
2 |
0 |
8 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
4 |
|
3D2K
|
17 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
6 |
0 |
17 |
12 |
|
AFP97477
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3D2I
|
19 |
0 |
0 |
0 |
17 |
0 |
0 |
4 |
0 |
4 |
0 |
19 |
20 |
|
3DJ5
|
22 |
26 |
13 |
0 |
19 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
18 |
|
3DJ7
|
21 |
10 |
17 |
0 |
18 |
0 |
0 |
13 |
0 |
2 |
0 |
10 |
8 |
|
3D15
|
22 |
25 |
21 |
0 |
17 |
0 |
0 |
15 |
0 |
5 |
0 |
29 |
8 |
|
3DJ6
|
19 |
18 |
13 |
0 |
16 |
0 |
0 |
7 |
0 |
0 |
0 |
0 |
18 |
|
3DAJ
|
17 |
0 |
9 |
0 |
17 |
0 |
0 |
0 |
0 |
5 |
0 |
11 |
19 |
|
3D14
|
27 |
3 |
3 |
0 |
16 |
0 |
0 |
11 |
0 |
0 |
0 |
14 |
15 |