- Protein Name
- Mitogen-activated protein kinase kinase kinase 5
- Gene Name
- MAP3K5
- Organism
-
Homo sapiens
- Function
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
23 |
1 |
12.0 |
| DFG |
20 |
2 |
14.0 |
| PIF |
11 |
7 |
9.5 |
| DRS |
15 |
2 |
3.0 |
| DEF |
15 |
14 |
14.5 |
| EDI |
7 |
2 |
7.0 |
| MT3 |
27 |
2 |
11.0 |
| AAS |
15 |
15 |
15.0 |
| PDIG |
12 |
4 |
8.0 |
| ATP |
21 |
3 |
12.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
6 |
1 |
0 |
0 |
0 |
0 |
5 |
0 |
0 |
0 |
0 |
7 |
0 |
|
4BF2
|
13 |
14 |
0 |
2 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
16 |
0 |
|
3VW6
|
12 |
20 |
0 |
15 |
14 |
7 |
7 |
0 |
0 |
0 |
12 |
17 |
0 |
|
4BIB
|
16 |
14 |
0 |
3 |
0 |
7 |
18 |
15 |
0 |
0 |
0 |
19 |
0 |
|
4BIE
|
23 |
15 |
0 |
2 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
21 |
0 |
|
2CLQ
|
18 |
0 |
11 |
3 |
15 |
0 |
27 |
0 |
0 |
0 |
4 |
16 |
0 |
|
4BIC
|
17 |
8 |
10 |
4 |
0 |
0 |
24 |
0 |
0 |
0 |
0 |
17 |
0 |
|
4BID
|
16 |
2 |
9 |
0 |
0 |
0 |
21 |
0 |
0 |
0 |
0 |
17 |
0 |
|
4BHN
|
16 |
0 |
0 |
0 |
0 |
0 |
15 |
15 |
0 |
0 |
0 |
15 |
0 |