P11362

Background

Protein Name
Fibroblast growth factor receptor 1
Gene Name
FGFR1
Organism
Homo sapiens

Annotations

Function
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

Mapping Statistics

Site
Maximum Consensus Site Population
Minimum Consensus Site Population
Median Consensus Site Population
EDI 16 3 10.0
MT3 21 2 8.0
PIF 17 7 16.0
ATP 28 2 12.0
DEF 17 2 4.0
DRS 7 2 4.0
AAS 20 2 10.0
MPP 32 2 14.5
DFG 16 3 9.5
LBP 4 4 4.0
CMP 22 2 4.0

Mapping Results

PDB ID
Maximum Consensus Site Population
EDI site
MT3 site
PIF site
ATP site
DEF site
DRS site
AAS site
MPP site
DFG site
LBP site
CMP site
PDIG site
PMP site
Total Druggable Structures per Site 2 4 2 13 1 0 2 32 1 0 2 0 0
1AGW 13 3 0 9 0 2 0 16 10 0 0 0 0
1FGI 10 21 0 21 3 0 2 17 11 0 0 0 0
1FGK 14 3 0 9 3 4 0 16 13 0 0 0 0
2FGI 12 4 0 13 0 0 0 16 12 0 0 0 0
3C4F 7 9 0 14 0 0 0 16 10 0 0 0 0
3DPK 0 7 0 17 0 0 0 15 0 0 0 0 0
3GQI 9 0 16 15 2 0 0 32 0 0 19 0 0
3GQL 10 13 0 16 0 5 13 23 15 0 22 0 0
3JS2 5 4 0 16 0 0 0 19 15 0 5 0 0
3KXX 14 0 17 17 17 2 0 29 9 4 3 0 0
3KY2 0 5 0 14 0 0 20 18 14 0 3 0 0
3RHX 12 0 0 16 0 7 0 25 12 0 0 0 0
3TT0 16 18 0 19 0 0 11 17 9 0 7 0 0
4F63 0 17 0 2 0 4 0 16 13 0 0 0 0
4F64 16 10 0 11 4 6 0 16 14 0 0 0 0
4F65 9 19 0 19 0 0 16 16 14 0 10 0 0
4NK9 14 11 0 14 0 2 0 24 12 0 0 0 0
4NKA 14 0 0 12 0 0 0 15 4 0 0 0 0
4NKS 10 0 0 16 0 0 0 18 8 0 0 0 0
4RWI 0 0 0 6 0 0 4 15 10 0 0 0 0
4RWJ 0 0 0 21 0 0 10 21 9 0 0 0 0
4RWK 0 0 0 13 0 0 0 15 0 0 0 0 0
4RWL 0 2 0 13 0 0 0 26 14 0 0 0 0
4UWB 0 3 0 9 0 0 12 31 12 0 0 0 0
4UWC 0 0 0 28 0 0 2 29 8 0 0 0 0
4UWY 0 0 0 0 0 0 0 20 4 0 0 0 0
4WUN 11 11 0 15 0 0 0 16 5 0 3 0 0
4ZSA 0 15 0 12 0 0 0 17 9 0 0 0 0
5A4C 0 0 0 16 0 0 0 18 14 0 0 0 0
5A46 0 0 0 15 0 0 0 17 9 0 0 0 0
5AM6 0 0 0 0 0 0 0 16 9 0 0 0 0
5AM7 0 0 0 0 0 0 0 16 0 0 0 0 0
5B7V 10 0 0 16 0 0 0 17 16 0 0 0 0
5EW8 0 0 0 14 0 0 0 29 8 0 0 0 0
5FLF 0 0 0 0 0 0 0 30 0 0 0 0 0
AFP11362 0 0 0 0 0 0 0 24 0 0 0 0 0