P29597

Background

Protein Name
Non-receptor tyrosine-protein kinase TYK2
Gene Name
TYK2
Organism
Homo sapiens

Annotations

Function
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 22 2 16.0
DFG 21 2 13.0
PIF 12 5 7.0
DRS 20 16 17.0
DEF 2 2 2.0
MT3 22 2 9.0
AAS 18 2 7.0
LBP 13 2 12.0
CMP 12 2 3.0
PDIG 20 2 5.0
ATP 26 2 8.5

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site DFG site PIF site DRS site DEF site EDI site MT3 site AAS site LBP site CMP site PDIG site ATP site PMP site
Total Druggable Structures per Site 5 8 0 3 0 0 3 2 0 0 1 6 0
5C03 16 9 0 16 0 0 22 0 0 0 20 4 0
4OLI 0 6 5 0 0 0 14 18 0 0 2 18 0
5C01 21 13 0 20 0 0 9 0 11 2 0 4 0
4GJ2 0 17 0 0 0 0 0 2 0 4 0 16 0
4GIH 0 21 0 0 0 0 0 6 0 0 0 16 0
3LXP 0 19 9 0 0 0 2 16 0 2 6 14 0
3LXN 0 15 0 0 0 0 9 3 0 12 0 12 0
4GVJ 0 16 0 0 2 0 0 5 0 0 4 14 0
4GII 0 21 0 0 0 0 0 7 2 0 0 15 0
4GJ3 16 6 0 0 0 0 0 4 0 3 2 12 0
3ZON 22 0 5 17 0 0 18 0 13 0 0 5 0
4PY1 3 17 0 0 0 0 0 0 0 0 0 18 0
5F20 4 16 0 0 0 0 0 11 0 0 0 10 0
4GFO 0 16 12 0 0 0 0 0 0 0 13 20 0
3NZ0 0 12 0 0 0 0 10 13 0 11 5 5 0
3NYX 0 0 0 0 0 0 5 0 0 2 5 26 0
5F1Z 2 12 0 0 0 0 0 10 0 0 10 5 0
4WOV 20 0 7 0 0 0 19 0 13 0 0 2 0