P29597

Background

Protein Name
Non-receptor tyrosine-protein kinase TYK2
Gene Name
TYK2
Organism
Homo sapiens

Annotations

Function
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 22 2 16.0
AAS 18 2 7.0
MT3 22 2 9.0
LBP 13 2 12.0
ATP 26 2 8.5
DEF 2 2 2.0
DFG 21 2 13.0
CMP 12 2 3.0
DRS 20 16 17.0
PDIG 20 2 5.0
PIF 12 5 7.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site AAS site MT3 site LBP site ATP site DEF site DFG site CMP site PMP site EDI site DRS site PDIG site PIF site
Total Druggable Structures per Site 5 2 3 0 6 0 8 0 0 0 3 1 0
3LXP 0 16 2 0 14 0 19 2 0 0 0 6 9
3NYX 0 0 5 0 26 0 0 2 0 0 0 5 0
4GJ2 0 2 0 0 16 0 17 4 0 0 0 0 0
3NZ0 0 13 10 0 5 0 12 11 0 0 0 5 0
4OLI 0 18 14 0 18 0 6 0 0 0 0 2 5
5F20 4 11 0 0 10 0 16 0 0 0 0 0 0
5F1Z 2 10 0 0 5 0 12 0 0 0 0 10 0
3LXN 0 3 9 0 12 0 15 12 0 0 0 0 0
4GIH 0 6 0 0 16 0 21 0 0 0 0 0 0
5C01 21 0 9 11 4 0 13 2 0 0 20 0 0
3ZON 22 0 18 13 5 0 0 0 0 0 17 0 5
4GJ3 16 4 0 0 12 0 6 3 0 0 0 2 0
4WOV 20 0 19 13 2 0 0 0 0 0 0 0 7
4GFO 0 0 0 0 20 0 16 0 0 0 0 13 12
4PY1 3 0 0 0 18 0 17 0 0 0 0 0 0
4GII 0 7 0 2 15 0 21 0 0 0 0 0 0
4GVJ 0 5 0 0 14 2 16 0 0 0 0 4 0
5C03 16 0 22 0 4 0 9 0 0 0 16 20 0