- Protein Name
- Rho-associated protein kinase 1
- Gene Name
- ROCK1
- Organism
-
Homo sapiens
- Function
- Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| AAS |
17 |
2 |
8.0 |
| MT3 |
3 |
3 |
3.0 |
| LBP |
2 |
2 |
2.0 |
| ATP |
17 |
2 |
15.0 |
| CMP |
13 |
2 |
9.0 |
| EDI |
19 |
2 |
11.0 |
| DRS |
27 |
2 |
14.0 |
| PDIG |
21 |
2 |
8.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
1 |
0 |
0 |
8 |
0 |
0 |
0 |
0 |
2 |
11 |
2 |
0 |
|
3V8S
|
0 |
0 |
0 |
0 |
15 |
0 |
0 |
9 |
0 |
15 |
15 |
8 |
0 |
|
2V55
|
0 |
0 |
0 |
0 |
15 |
0 |
0 |
13 |
0 |
6 |
27 |
0 |
0 |
|
3TWJ
|
0 |
0 |
0 |
2 |
16 |
0 |
0 |
5 |
0 |
14 |
16 |
21 |
0 |
|
3NCZ
|
0 |
17 |
3 |
0 |
15 |
0 |
0 |
0 |
0 |
19 |
19 |
10 |
0 |
|
5BML
|
0 |
0 |
0 |
0 |
15 |
0 |
0 |
0 |
0 |
12 |
16 |
0 |
0 |
|
3TV7
|
0 |
10 |
0 |
0 |
17 |
0 |
0 |
9 |
0 |
16 |
19 |
20 |
0 |
|
2ESM
|
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
10 |
17 |
5 |
0 |
|
3NDM
|
0 |
0 |
0 |
0 |
17 |
0 |
0 |
2 |
0 |
0 |
19 |
2 |
0 |
|
4YVC
|
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
12 |
14 |
0 |
0 |
|
4W7P
|
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
11 |
16 |
0 |
0 |
|
2ETK
|
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
12 |
14 |
0 |
0 |
|
3D9V
|
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
11 |
23 |
0 |
0 |
|
4YVE
|
0 |
0 |
0 |
0 |
15 |
0 |
0 |
0 |
0 |
14 |
19 |
0 |
0 |
|
2ETR
|
0 |
2 |
0 |
0 |
15 |
0 |
0 |
0 |
0 |
10 |
25 |
0 |
0 |