- Protein Name
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
- Gene Name
- DYRK1A
- Organism
-
Homo sapiens
- Function
- May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MT3 |
18 |
2 |
5.0 |
| LBP |
9 |
2 |
6.0 |
| ATP |
27 |
1 |
15.0 |
| DFG |
24 |
1 |
8.5 |
| CMP |
19 |
14 |
16.0 |
| EDI |
17 |
1 |
16.0 |
| DRS |
12 |
2 |
6.0 |
| PDIG |
13 |
1 |
4.0 |
| PIF |
27 |
12 |
19.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
1 |
0 |
17 |
0 |
4 |
2 |
0 |
9 |
0 |
0 |
8 |
|
4YU2
|
0 |
0 |
5 |
0 |
17 |
0 |
0 |
0 |
0 |
16 |
7 |
0 |
16 |
|
AFQ13627
|
0 |
0 |
0 |
0 |
0 |
0 |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4NCT
|
0 |
0 |
0 |
0 |
17 |
0 |
7 |
0 |
0 |
15 |
9 |
0 |
0 |
|
3ANQ
|
0 |
0 |
7 |
9 |
18 |
0 |
0 |
0 |
0 |
17 |
9 |
0 |
0 |
|
4YLJ
|
0 |
0 |
5 |
2 |
18 |
0 |
4 |
0 |
0 |
13 |
7 |
2 |
22 |
|
4AZE
|
0 |
0 |
10 |
0 |
12 |
0 |
16 |
0 |
0 |
17 |
0 |
13 |
0 |
|
5A4Q
|
0 |
0 |
0 |
0 |
19 |
0 |
0 |
0 |
0 |
15 |
9 |
0 |
0 |
|
3ANR
|
0 |
0 |
2 |
9 |
21 |
0 |
9 |
17 |
0 |
17 |
7 |
0 |
0 |
|
5A4T
|
0 |
0 |
0 |
0 |
23 |
0 |
8 |
0 |
0 |
13 |
5 |
0 |
0 |
|
5A3X
|
0 |
0 |
0 |
5 |
15 |
0 |
0 |
0 |
0 |
15 |
3 |
0 |
19 |
|
4YLL
|
0 |
0 |
0 |
0 |
19 |
0 |
0 |
0 |
0 |
14 |
0 |
0 |
27 |
|
5A4L
|
0 |
0 |
0 |
0 |
17 |
0 |
9 |
15 |
0 |
17 |
8 |
0 |
0 |
|
2WO6
|
0 |
0 |
18 |
4 |
18 |
0 |
11 |
0 |
0 |
16 |
3 |
7 |
15 |
|
2VX3
|
0 |
0 |
12 |
8 |
19 |
0 |
17 |
0 |
0 |
16 |
2 |
1 |
19 |
|
4MQ1
|
0 |
0 |
4 |
0 |
27 |
0 |
0 |
0 |
0 |
17 |
6 |
4 |
22 |
|
4YLK
|
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |
21 |
|
5A4E
|
0 |
0 |
2 |
0 |
19 |
0 |
18 |
19 |
0 |
13 |
9 |
0 |
0 |
|
5AIK
|
0 |
0 |
0 |
7 |
17 |
0 |
0 |
0 |
0 |
15 |
4 |
6 |
0 |
|
4MQ2
|
0 |
0 |
0 |
0 |
20 |
0 |
1 |
0 |
0 |
17 |
12 |
8 |
24 |
|
5A54
|
0 |
0 |
0 |
4 |
16 |
0 |
2 |
0 |
0 |
14 |
3 |
0 |
0 |