- Protein Name
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
- Gene Name
- DYRK1A
- Organism
-
Homo sapiens
- Function
- May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
24 |
1 |
8.5 |
| PIF |
27 |
12 |
19.0 |
| DRS |
12 |
2 |
6.0 |
| EDI |
17 |
1 |
16.0 |
| MT3 |
18 |
2 |
5.0 |
| LBP |
9 |
2 |
6.0 |
| CMP |
19 |
14 |
16.0 |
| PDIG |
13 |
1 |
4.0 |
| ATP |
27 |
1 |
15.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
4 |
8 |
0 |
0 |
9 |
1 |
0 |
0 |
2 |
0 |
17 |
0 |
|
5A4L
|
0 |
9 |
0 |
8 |
0 |
17 |
0 |
0 |
0 |
15 |
0 |
17 |
0 |
|
5A3X
|
0 |
0 |
19 |
3 |
0 |
15 |
0 |
0 |
5 |
0 |
0 |
15 |
0 |
|
3ANR
|
0 |
9 |
0 |
7 |
0 |
17 |
2 |
0 |
9 |
17 |
0 |
21 |
0 |
|
5A4E
|
0 |
18 |
0 |
9 |
0 |
13 |
2 |
0 |
0 |
19 |
0 |
19 |
0 |
|
AFQ13627
|
0 |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4YU2
|
0 |
0 |
16 |
7 |
0 |
16 |
5 |
0 |
0 |
0 |
0 |
17 |
0 |
|
4MQ1
|
0 |
0 |
22 |
6 |
0 |
17 |
4 |
0 |
0 |
0 |
4 |
27 |
0 |
|
4YLK
|
0 |
0 |
21 |
0 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |
|
2VX3
|
0 |
17 |
19 |
2 |
0 |
16 |
12 |
0 |
8 |
0 |
1 |
19 |
0 |
|
5A4Q
|
0 |
0 |
0 |
9 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |
19 |
0 |
|
3ANQ
|
0 |
0 |
0 |
9 |
0 |
17 |
7 |
0 |
9 |
0 |
0 |
18 |
0 |
|
2WO6
|
0 |
11 |
15 |
3 |
0 |
16 |
18 |
0 |
4 |
0 |
7 |
18 |
0 |
|
4MQ2
|
0 |
1 |
24 |
12 |
0 |
17 |
0 |
0 |
0 |
0 |
8 |
20 |
0 |
|
4NCT
|
0 |
7 |
0 |
9 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
|
5A4T
|
0 |
8 |
0 |
5 |
0 |
13 |
0 |
0 |
0 |
0 |
0 |
23 |
0 |
|
5AIK
|
0 |
0 |
0 |
4 |
0 |
15 |
0 |
0 |
7 |
0 |
6 |
17 |
0 |
|
4AZE
|
0 |
16 |
0 |
0 |
0 |
17 |
10 |
0 |
0 |
0 |
13 |
12 |
0 |
|
5A54
|
0 |
2 |
0 |
3 |
0 |
14 |
0 |
0 |
4 |
0 |
0 |
16 |
0 |
|
4YLL
|
0 |
0 |
27 |
0 |
0 |
14 |
0 |
0 |
0 |
0 |
0 |
19 |
0 |
|
4YLJ
|
0 |
4 |
22 |
7 |
0 |
13 |
5 |
0 |
2 |
0 |
2 |
18 |
0 |