- Protein Name
- Aurora kinase B-A
- Gene Name
- aurkb-a
- Organism
-
Xenopus laevis
- Function
- Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Phosphorylates 'Ser-10' of histone H3 during mitosis.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
16 |
7 |
11.5 |
| DFG |
2 |
2 |
2.0 |
| PIF |
16 |
4 |
12.0 |
| EDI |
14 |
5 |
8.0 |
| MT3 |
14 |
2 |
5.0 |
| AAS |
14 |
8 |
9.0 |
| CMP |
15 |
3 |
7.0 |
| PDIG |
25 |
4 |
18.0 |
| ATP |
19 |
3 |
16.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
4 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
9 |
9 |
0 |
|
2VGP
|
15 |
0 |
14 |
0 |
0 |
7 |
5 |
9 |
0 |
0 |
21 |
16 |
0 |
|
4B8L
|
16 |
2 |
15 |
0 |
0 |
8 |
14 |
0 |
0 |
15 |
14 |
16 |
0 |
|
3ZTX
|
10 |
0 |
13 |
0 |
0 |
13 |
6 |
11 |
0 |
5 |
23 |
18 |
0 |
|
2BFX
|
15 |
0 |
16 |
0 |
0 |
14 |
7 |
14 |
0 |
6 |
21 |
16 |
0 |
|
2BFY
|
16 |
2 |
15 |
0 |
0 |
11 |
12 |
14 |
0 |
8 |
25 |
19 |
0 |
|
2VGO
|
16 |
0 |
15 |
0 |
0 |
11 |
4 |
11 |
0 |
7 |
23 |
17 |
0 |
|
4B8M
|
9 |
0 |
14 |
0 |
0 |
12 |
3 |
8 |
0 |
3 |
19 |
16 |
0 |
|
AFQ6DE08
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4C2W
|
13 |
0 |
16 |
0 |
0 |
6 |
0 |
8 |
0 |
7 |
25 |
16 |
0 |
|
4C2V
|
11 |
0 |
13 |
0 |
0 |
7 |
13 |
11 |
0 |
7 |
23 |
15 |
0 |
|
2VRX
|
16 |
0 |
13 |
0 |
0 |
14 |
14 |
11 |
0 |
6 |
18 |
16 |
0 |