- Protein Name
- Activin receptor type-1
- Gene Name
- ACVR1
- Organism
-
Homo sapiens
- Function
- On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
16 |
2 |
10.5 |
| DFG |
29 |
1 |
18.0 |
| PIF |
10 |
7 |
9.0 |
| DRS |
4 |
4 |
4.0 |
| DEF |
10 |
10 |
10.0 |
| EDI |
18 |
5 |
14.0 |
| MT3 |
2 |
1 |
2.0 |
| AAS |
18 |
3 |
11.0 |
| LBP |
7 |
7 |
7.0 |
| CMP |
16 |
3 |
9.5 |
| ATP |
28 |
2 |
15.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
2 |
5 |
0 |
0 |
0 |
4 |
0 |
2 |
0 |
1 |
0 |
7 |
0 |
|
4DYM
|
16 |
18 |
0 |
0 |
0 |
16 |
0 |
14 |
0 |
0 |
0 |
28 |
0 |
|
AFQ04771
|
0 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3OOM
|
0 |
24 |
0 |
0 |
10 |
14 |
1 |
14 |
0 |
0 |
0 |
17 |
0 |
|
3Q4U
|
16 |
21 |
9 |
0 |
0 |
17 |
2 |
16 |
0 |
0 |
0 |
26 |
0 |
|
4C02
|
0 |
2 |
0 |
0 |
0 |
14 |
0 |
0 |
7 |
0 |
0 |
24 |
0 |
|
3MTF
|
0 |
22 |
0 |
4 |
0 |
18 |
0 |
18 |
0 |
0 |
0 |
16 |
0 |
|
4BGG
|
5 |
29 |
7 |
0 |
0 |
16 |
2 |
14 |
0 |
16 |
0 |
18 |
0 |
|
3H9R
|
0 |
8 |
10 |
0 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |
21 |
0 |