- Protein Name
- Tyrosine-protein kinase ITK/TSK
- Gene Name
- ITK
- Organism
-
Homo sapiens
- Function
- Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
11 |
2 |
6.5 |
| DFG |
5 |
1 |
3.0 |
| PIF |
19 |
4 |
10.0 |
| DRS |
16 |
2 |
12.5 |
| DEF |
7 |
7 |
7.0 |
| EDI |
14 |
2 |
3.0 |
| MT3 |
24 |
1 |
9.0 |
| AAS |
20 |
2 |
11.0 |
| LBP |
5 |
2 |
3.0 |
| CMP |
11 |
3 |
7.0 |
| PDIG |
23 |
2 |
16.0 |
| ATP |
31 |
2 |
13.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
1 |
7 |
0 |
0 |
8 |
5 |
0 |
0 |
9 |
19 |
0 |
|
4PP9
|
8 |
0 |
0 |
16 |
0 |
0 |
2 |
8 |
0 |
8 |
0 |
19 |
0 |
|
3V8W
|
0 |
0 |
4 |
14 |
0 |
0 |
13 |
17 |
0 |
0 |
7 |
15 |
0 |
|
1SM2
|
0 |
0 |
0 |
14 |
0 |
0 |
18 |
9 |
5 |
11 |
20 |
25 |
0 |
|
3QGW
|
0 |
0 |
0 |
14 |
7 |
4 |
15 |
6 |
0 |
3 |
17 |
19 |
0 |
|
4HCV
|
0 |
0 |
0 |
0 |
0 |
0 |
24 |
0 |
0 |
0 |
0 |
16 |
0 |
|
4PQN
|
11 |
0 |
0 |
14 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
27 |
0 |
|
4M13
|
0 |
0 |
0 |
11 |
0 |
3 |
22 |
0 |
0 |
0 |
0 |
7 |
0 |
|
4L7S
|
0 |
0 |
0 |
16 |
0 |
0 |
3 |
15 |
0 |
0 |
16 |
26 |
0 |
|
4M15
|
0 |
0 |
0 |
3 |
0 |
3 |
9 |
0 |
0 |
0 |
0 |
5 |
0 |
|
4PPC
|
0 |
0 |
0 |
13 |
0 |
2 |
0 |
3 |
0 |
5 |
0 |
0 |
0 |
|
3V5J
|
8 |
1 |
0 |
16 |
0 |
2 |
6 |
13 |
0 |
3 |
17 |
26 |
0 |
|
4HCU
|
0 |
0 |
0 |
0 |
0 |
0 |
19 |
0 |
0 |
0 |
0 |
13 |
0 |
|
4M0Z
|
0 |
0 |
0 |
13 |
0 |
3 |
15 |
0 |
0 |
0 |
0 |
8 |
0 |
|
1SNX
|
4 |
0 |
8 |
0 |
0 |
14 |
22 |
12 |
2 |
0 |
23 |
25 |
0 |
|
4M12
|
0 |
0 |
0 |
7 |
0 |
0 |
8 |
0 |
0 |
0 |
0 |
6 |
0 |
|
4HCT
|
0 |
0 |
0 |
0 |
0 |
0 |
14 |
0 |
0 |
0 |
0 |
16 |
0 |
|
AFQ08881
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3V8T
|
5 |
0 |
10 |
16 |
0 |
0 |
9 |
14 |
0 |
0 |
16 |
31 |
0 |
|
4PPB
|
0 |
0 |
0 |
9 |
0 |
0 |
0 |
16 |
0 |
10 |
0 |
0 |
0 |
|
4QD6
|
0 |
0 |
0 |
10 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
0 |
0 |
|
3MIY
|
0 |
0 |
0 |
16 |
0 |
2 |
0 |
12 |
0 |
7 |
0 |
24 |
0 |
|
4PPA
|
0 |
0 |
0 |
8 |
0 |
0 |
0 |
14 |
0 |
8 |
0 |
0 |
0 |
|
4RFM
|
0 |
0 |
4 |
6 |
0 |
0 |
19 |
12 |
0 |
0 |
0 |
24 |
0 |
|
4M0Y
|
0 |
0 |
0 |
4 |
0 |
6 |
9 |
2 |
0 |
0 |
0 |
11 |
0 |
|
3QGY
|
0 |
5 |
0 |
14 |
0 |
0 |
0 |
11 |
0 |
0 |
16 |
16 |
0 |
|
3MJ2
|
0 |
0 |
0 |
0 |
0 |
0 |
23 |
0 |
0 |
0 |
0 |
21 |
0 |
|
4MF1
|
2 |
0 |
0 |
16 |
0 |
0 |
0 |
13 |
0 |
8 |
0 |
15 |
0 |
|
4MF0
|
0 |
0 |
0 |
14 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
0 |
0 |
|
3T9T
|
0 |
0 |
0 |
0 |
0 |
0 |
8 |
0 |
0 |
0 |
0 |
16 |
0 |
|
3V5L
|
5 |
0 |
12 |
16 |
0 |
0 |
3 |
19 |
0 |
4 |
16 |
16 |
0 |
|
1SNU
|
0 |
0 |
19 |
0 |
0 |
11 |
20 |
11 |
3 |
8 |
16 |
22 |
0 |
|
3MJ1
|
0 |
0 |
0 |
13 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
24 |
0 |
|
4KIO
|
9 |
0 |
0 |
10 |
0 |
0 |
0 |
13 |
0 |
8 |
0 |
20 |
0 |
|
4M14
|
0 |
0 |
0 |
6 |
0 |
3 |
12 |
0 |
0 |
0 |
0 |
0 |
0 |