Q9NZJ5

Background

Protein Name
Eukaryotic translation initiation factor 2-alpha kinase 3
Gene Name
EIF2AK3
Organism
Homo sapiens

Annotations

Function
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MT3 23 2 15.0
ATP 21 2 14.5
DRS 17 2 10.0
AAS 10 5 7.0
MPP 3 3 3.0
PDIG 14 4 5.0

Mapping Results

PDB ID Maximum Consensus Site Population
EDI site MT3 site PIF site ATP site DEF site DRS site AAS site MPP site DFG site LBP site CMP site PDIG site PMP site
Total Druggable Structures per Site 0 8 0 2 0 1 0 0 0 0 0 0 0
4X7O 0 20 0 13 0 11 6 0 0 0 0 14 0
4X7J 0 23 0 15 0 13 0 0 0 0 0 0 0
4X7L 0 17 0 21 0 9 0 0 0 0 0 0 0
4G34 0 11 0 18 0 15 8 0 0 0 0 0 0
4X7N 0 16 0 15 0 8 5 0 0 0 0 0 0
AFQ9NZJ5 0 0 0 0 0 0 0 0 0 0 0 0 0
4G31 0 16 0 13 0 17 10 3 0 0 0 0 0
4M7I 0 17 0 14 0 13 10 0 0 0 0 4 0
4X7H 0 23 0 0 0 9 7 0 0 0 0 5 0
4X7K 0 19 0 0 0 10 5 0 0 0 0 0 0