P21802

Background

Protein Name
Fibroblast growth factor receptor 2
Gene Name
FGFR2
Organism
Homo sapiens

Annotations

Function
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

Mapping Statistics

Site
Maximum Consensus Site Population
Minimum Consensus Site Population
Median Consensus Site Population
EDI 14 3 11.0
PIF 30 17 19.5
ATP 19 2 11.0
DEF 19 1 13.0
DRS 20 2 4.0
AAS 4 4 4.0
MPP 30 1 12.0
DFG 13 1 4.5
LBP 9 2 4.0
CMP 16 5 6.0

Mapping Results

PDB ID
Maximum Consensus Site Population
EDI site
MT3 site
PIF site
ATP site
DEF site
DRS site
AAS site
MPP site
DFG site
LBP site
CMP site
PDIG site
PMP site
Total Druggable Structures per Site 0 0 9 6 4 1 0 10 0 0 1 0 0
1GJO 0 0 0 19 18 0 0 15 0 0 0 0 0
1OEC 0 0 0 15 19 5 0 25 0 0 0 0 0
2PSQ 13 0 0 13 0 0 0 18 7 9 0 0 0
2PVF 6 0 0 13 0 3 0 8 3 0 0 0 0
2PVY 10 0 19 14 16 2 4 20 2 0 16 0 0
2PWL 12 0 0 18 0 3 0 29 0 0 0 0 0
2PY3 13 0 21 14 0 4 0 16 4 9 0 0 0
2PZ5 11 0 23 14 0 3 0 13 8 0 8 0 0
2PZP 11 0 21 19 0 5 0 9 5 7 6 0 0
2PZR 12 0 19 11 0 11 0 14 10 4 0 0 0
2Q0B 9 0 22 16 0 5 0 14 0 5 5 0 0
3B2T 0 0 20 11 12 3 0 17 3 0 0 0 0
3CLY 6 0 0 13 0 4 0 15 2 0 0 0 0
3RI1 13 0 0 16 0 0 0 21 10 2 0 0 0
4J95 14 0 0 13 0 5 0 7 13 2 0 0 0
4J96 11 0 30 16 2 7 0 18 5 0 0 0 0
4J97 5 0 19 13 4 0 0 30 2 0 0 0 0
4J98 3 0 0 15 14 8 0 17 7 0 0 0 0
4J99 14 0 0 11 0 20 0 12 8 0 0 0 0
5EG3 0 0 0 15 17 0 0 13 2 0 0 0 0
AFP21802 0 0 0 0 0 0 0 0 0 0 0 0 0