- Protein Name
- Cyclin-dependent kinase 8
- Gene Name
- CDK8
- Organism
-
Homo sapiens
- Function
- Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
22 |
2 |
12.0 |
| DFG |
21 |
2 |
10.0 |
| DRS |
11 |
2 |
5.0 |
| EDI |
17 |
2 |
10.0 |
| MT3 |
27 |
2 |
7.0 |
| AAS |
22 |
1 |
9.0 |
| LBP |
12 |
2 |
3.0 |
| CMP |
19 |
2 |
11.0 |
| PDIG |
23 |
2 |
12.0 |
| ATP |
24 |
1 |
16.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
4 |
1 |
0 |
0 |
0 |
7 |
4 |
5 |
0 |
1 |
8 |
15 |
0 |
|
5BNJ
|
12 |
0 |
0 |
0 |
0 |
14 |
3 |
7 |
2 |
12 |
7 |
19 |
0 |
|
4G6L
|
16 |
0 |
0 |
0 |
0 |
16 |
12 |
22 |
0 |
0 |
2 |
22 |
0 |
|
AFP49336
|
22 |
21 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4F7L
|
17 |
0 |
0 |
5 |
0 |
16 |
22 |
3 |
4 |
0 |
21 |
6 |
0 |
|
4CRL
|
0 |
0 |
0 |
0 |
0 |
17 |
5 |
5 |
0 |
0 |
13 |
16 |
0 |
|
5I5Z
|
10 |
0 |
0 |
11 |
0 |
11 |
0 |
16 |
3 |
13 |
4 |
18 |
0 |
|
4F7J
|
8 |
2 |
0 |
0 |
0 |
10 |
3 |
14 |
3 |
0 |
23 |
19 |
0 |
|
5HBE
|
7 |
0 |
0 |
0 |
0 |
11 |
0 |
16 |
2 |
19 |
3 |
23 |
0 |
|
4F7S
|
12 |
0 |
0 |
0 |
0 |
14 |
22 |
7 |
12 |
10 |
0 |
5 |
0 |
|
4F70
|
2 |
0 |
0 |
0 |
0 |
16 |
9 |
0 |
0 |
0 |
16 |
24 |
0 |
|
5HBJ
|
0 |
0 |
0 |
4 |
0 |
15 |
7 |
13 |
3 |
0 |
11 |
17 |
0 |
|
4F6S
|
8 |
0 |
0 |
0 |
0 |
10 |
16 |
10 |
0 |
0 |
12 |
14 |
0 |
|
5FGK
|
0 |
0 |
0 |
2 |
0 |
17 |
4 |
15 |
0 |
0 |
16 |
16 |
0 |
|
4F6U
|
15 |
0 |
0 |
3 |
0 |
12 |
9 |
16 |
0 |
0 |
16 |
12 |
0 |
|
5HBH
|
14 |
0 |
0 |
0 |
0 |
13 |
10 |
5 |
0 |
2 |
11 |
16 |
0 |
|
5CEI
|
0 |
0 |
0 |
9 |
0 |
14 |
0 |
9 |
4 |
7 |
0 |
21 |
0 |
|
3RGF
|
14 |
0 |
0 |
0 |
0 |
13 |
0 |
12 |
2 |
0 |
18 |
18 |
0 |
|
4F6W
|
9 |
0 |
0 |
0 |
0 |
16 |
27 |
15 |
0 |
0 |
13 |
9 |
0 |
|
4F7N
|
11 |
0 |
0 |
0 |
0 |
12 |
8 |
16 |
2 |
0 |
23 |
18 |
0 |
|
5HVY
|
0 |
0 |
0 |
0 |
0 |
16 |
3 |
3 |
0 |
0 |
11 |
17 |
0 |
|
5HNB
|
18 |
0 |
0 |
8 |
0 |
15 |
0 |
8 |
4 |
0 |
18 |
22 |
0 |