- Protein Name
- Dual specificity protein kinase TTK
- Gene Name
- TTK
- Organism
-
Homo sapiens
- Function
- Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
18 |
7 |
15.0 |
| AAS |
25 |
2 |
5.0 |
| MT3 |
20 |
2 |
8.0 |
| ATP |
29 |
2 |
17.0 |
| DEF |
2 |
2 |
2.0 |
| DFG |
16 |
2 |
9.0 |
| CMP |
18 |
3 |
14.0 |
| EDI |
23 |
1 |
16.0 |
| DRS |
3 |
3 |
3.0 |
| PDIG |
27 |
1 |
12.0 |
| PIF |
4 |
4 |
4.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
15 |
9 |
3 |
0 |
42 |
0 |
2 |
2 |
0 |
44 |
0 |
9 |
0 |
|
AFP33981
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3HMP
|
16 |
3 |
11 |
0 |
20 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
|
4C4G
|
7 |
0 |
9 |
0 |
17 |
0 |
9 |
0 |
0 |
16 |
0 |
3 |
0 |
|
4C4J
|
18 |
6 |
0 |
0 |
21 |
0 |
15 |
0 |
0 |
18 |
0 |
0 |
0 |
|
4CVA
|
16 |
11 |
7 |
0 |
20 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
|
5AP6
|
13 |
2 |
0 |
0 |
17 |
0 |
11 |
14 |
0 |
14 |
0 |
0 |
0 |
|
3WYY
|
15 |
14 |
9 |
0 |
19 |
0 |
3 |
5 |
0 |
20 |
0 |
6 |
0 |
|
5AP7
|
12 |
0 |
10 |
0 |
16 |
0 |
0 |
13 |
0 |
18 |
0 |
24 |
0 |
|
4C4E
|
16 |
25 |
8 |
0 |
28 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
|
3WYX
|
15 |
13 |
6 |
0 |
25 |
0 |
0 |
0 |
0 |
18 |
0 |
12 |
0 |
|
3DBQ
|
15 |
20 |
5 |
0 |
20 |
0 |
0 |
3 |
0 |
16 |
0 |
27 |
0 |
|
4BI1
|
16 |
3 |
6 |
0 |
29 |
0 |
14 |
0 |
0 |
17 |
0 |
13 |
0 |
|
5AP0
|
14 |
23 |
12 |
0 |
16 |
0 |
4 |
0 |
0 |
16 |
0 |
0 |
0 |
|
4CV9
|
15 |
13 |
9 |
0 |
16 |
0 |
0 |
0 |
0 |
19 |
0 |
0 |
0 |
|
4BHZ
|
0 |
2 |
5 |
0 |
27 |
0 |
0 |
0 |
0 |
20 |
0 |
4 |
0 |
|
2ZMD
|
8 |
0 |
20 |
0 |
27 |
0 |
3 |
0 |
0 |
21 |
0 |
15 |
0 |
|
5EI2
|
0 |
0 |
4 |
0 |
17 |
0 |
3 |
15 |
0 |
19 |
0 |
2 |
0 |
|
3WZJ
|
0 |
0 |
17 |
0 |
20 |
0 |
0 |
17 |
0 |
20 |
0 |
1 |
0 |
|
4C4F
|
15 |
17 |
15 |
0 |
16 |
0 |
5 |
0 |
0 |
19 |
0 |
2 |
0 |
|
2X9E
|
18 |
19 |
13 |
0 |
18 |
0 |
0 |
0 |
0 |
23 |
0 |
21 |
0 |
|
5AP3
|
16 |
24 |
10 |
0 |
29 |
0 |
0 |
0 |
0 |
18 |
0 |
14 |
0 |
|
3W1F
|
0 |
11 |
8 |
0 |
15 |
0 |
14 |
0 |
0 |
8 |
0 |
12 |
0 |
|
3GFW
|
17 |
0 |
9 |
0 |
19 |
0 |
7 |
0 |
0 |
17 |
0 |
0 |
0 |
|
3VQU
|
0 |
15 |
4 |
0 |
18 |
0 |
0 |
0 |
0 |
17 |
0 |
17 |
0 |
|
4BI0
|
15 |
0 |
8 |
0 |
26 |
0 |
3 |
0 |
0 |
16 |
0 |
3 |
0 |
|
5EHY
|
15 |
0 |
10 |
0 |
16 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
|
5EI6
|
16 |
2 |
14 |
0 |
16 |
0 |
8 |
6 |
0 |
17 |
0 |
0 |
0 |
|
4CV8
|
15 |
5 |
12 |
0 |
17 |
0 |
14 |
14 |
0 |
18 |
0 |
12 |
0 |
|
4D2S
|
14 |
8 |
12 |
0 |
18 |
0 |
12 |
0 |
0 |
18 |
0 |
0 |
0 |
|
3HMN
|
16 |
4 |
9 |
0 |
22 |
0 |
8 |
0 |
0 |
17 |
0 |
15 |
0 |
|
4ZEG
|
15 |
8 |
14 |
0 |
16 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
|
5EI8
|
9 |
5 |
8 |
0 |
15 |
0 |
8 |
0 |
0 |
18 |
0 |
16 |
0 |
|
4JT3
|
0 |
11 |
9 |
0 |
23 |
0 |
0 |
0 |
0 |
16 |
0 |
2 |
0 |
|
5AP2
|
11 |
0 |
0 |
0 |
18 |
0 |
16 |
0 |
0 |
19 |
0 |
11 |
0 |
|
5EH0
|
15 |
10 |
13 |
0 |
18 |
0 |
9 |
0 |
0 |
16 |
0 |
17 |
0 |
|
3H9F
|
18 |
14 |
0 |
0 |
22 |
0 |
16 |
0 |
0 |
15 |
0 |
14 |
0 |
|
4C4H
|
0 |
0 |
16 |
0 |
17 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
|
4C4I
|
0 |
4 |
7 |
0 |
18 |
0 |
11 |
0 |
0 |
16 |
0 |
0 |
0 |
|
3WZK
|
0 |
3 |
15 |
0 |
16 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
|
4BI2
|
0 |
3 |
10 |
0 |
17 |
0 |
2 |
0 |
0 |
19 |
0 |
18 |
0 |
|
5AP1
|
17 |
5 |
15 |
0 |
15 |
0 |
0 |
18 |
0 |
18 |
0 |
0 |
0 |
|
5AP5
|
0 |
0 |
9 |
0 |
12 |
2 |
5 |
0 |
0 |
18 |
3 |
19 |
0 |
|
3HMO
|
15 |
3 |
11 |
0 |
20 |
0 |
13 |
0 |
0 |
17 |
0 |
14 |
0 |
|
3CEK
|
16 |
8 |
10 |
0 |
21 |
0 |
12 |
0 |
0 |
17 |
0 |
0 |
0 |
|
4JS8
|
10 |
16 |
12 |
0 |
13 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
|
5AP4
|
14 |
19 |
15 |
0 |
17 |
0 |
15 |
0 |
0 |
18 |
0 |
10 |
0 |
|
4O6L
|
17 |
17 |
6 |
0 |
29 |
0 |
0 |
0 |
0 |
17 |
0 |
9 |
0 |
|
2ZMC
|
18 |
11 |
8 |
0 |
20 |
0 |
10 |
0 |
0 |
22 |
0 |
18 |
4 |